(71) Kacso, G., Ravasz, D., Doczi, J., Nﾃｩmeth, B., Madgar, O.,
Saada, A., Ilin, P., Miller, C., Ostergaard, E., Iordanov, I.,
Adams, D., Vargedo, Z., Araki, M., Araki, K., Nakahara, M.,
Ito, H., Gal, A., Molnar, MJ., Nagy, Z., Patocs, A.,
Adam-Vizi, V., Chinopoulos, C.,
Two transgenic mouse models for beta subunit components of
succinate-CoA ligase yielding pleiotropic metabolic alterations.
Biochemical J. 2016 Aug 5 (2016).
(70) Vanhoutteghem, A., Delhomme, B., Herve, F., Nondier, I.,
Petit, JM., Araki, M., Araki, K., Djian, P.,
The importance of basonuclin 2 in adult mice and its
relation to basonuclin 1.
Mechanisms of Development, 2016 Feb 29 (2016).
(69) Nakakura, S., Matsui, M., Sato, A., Ishii, M., Endo, K.,
Muragishi, S., Murase, M., Kito, H., Niguma, H., Kurokawa, N.,
Fujii, M., Araki, M., Araki, K., Ohya, S.,
Pathophysiological significance of the two-pore domain
K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset
from a chemically-induced murine inflammatery bowel disease model.
Frontiers in Physiology, 6, 299 (2015).
(68) amarena, V., Cao, L., Abad, C., Abrams, A., Toledo, Y.,
Araki, K., Araki, M., Walz, K., Young, JI.,
Disruption of Mbd5 in mice causes neuronal functional
deficits and neurobehavioral abnormalities consistent with 2q23.1
microdeletion syndrome.
EMBO Mol. Med., 6 (8), 1003-1015 (2014).
(67) Lu, J., He, L., Behrends, C., Araki, M., Araki, K.,
Jun Wang, Q., Catanzaro, JM., Friedman, SL., Zong, WX.,
Fiel, MI., Li, M., Yue, Z.,
NRBF2 regulates autophagy and prevents liver injury by modulating
Atg14L-linked phosphatidylinositol-3 kinase III activity.
Nature Communication, 5, 3920 (2014).
(66) Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K.,
Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M.,
Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y.,
Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y.,
Tominaga, T., Miyagi, S., Kawagisihi, N., Saga, T., Ohkubo, T.,
Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T.,
Mount, DB., Bonventre, JV., Ito, S., Tomioka, Y., Ito, K., Abe, T.,
Conformational Change in Transfer RNA Is an Early Indicator
of Acute Cellular Damage.
J. Am. Soc. Nephrology, 25 (10), 2316-2326 (2014).
(65) Schneppenheim, J., Huttl, S., Mentrup, T., Lullmann-Rauch, R.,
Rothaug, M., Engelke, M., Dittmann, K., Dressel, R., Araki, M.,
Araki, K., Wienands, J., Fluhrer, R., Saftig, P., Schroder, B.,
The intramembrane proteases Signal-peptide-peptidase-like 2a
and b (SPPL2a/b) have distinct functions in vivo.
Mol. Cell. Biol., 34 (8), 1398-1411 (2014).
(64) Araki, M., Nakahara, M., Muta, M., Itou, M., Yanai, C.,
Yamazoe, F., Miyake, M., Morita, A., Araki, M., Okamoto, Y.,
Nakagata, N., Yoshinobu, K., Yamamura, K., Araki, K.,
Database for exchangeable gene trap clones: Pathway and
gene ontology analysis of exchangeable gene trap clone mouse lines.
Dev. Growth Differ., 56, 161-174 (2014).
(63) Nakahara, M., Tateyama, H., Araki, M., Nakagata, N.,
Yamamura, K., Araki, K.,
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells
from MSM/Ms mice.
Mamm. Genome, 24, 228-239 (2013).
(62) Kappei, D., Butter, F., Benda, C., Scheibe, M., Draskovic, I.,
Stevense, M., Novo, C. L., Basquin, C., Araki, M., Araki, K.,
Krastev, D. B., Kittler, R., Jessberger, R., Londono-Vallejo, J. A.,
Mann, M., Buchholz, F.,
HOT1 is a mammalian direct telomere repeat-binding protein
contributing to telomerase recruitment.
EMBO J., 32, 1682-1701 (2013).
(61) Cid, L. P., Roa-Rojas, H. A., Niemeyer, M. I., Gonzalez, W.,
Araki, M., Araki, K., Sepulveda, F. V.,
TASK-2: a K2P K(+) channel with complex regulation and diverse
physiological functions.
Front. Physiol., 4, 198 (2013).
(60) Nam, G., Lee, Y. K., Lee, H. Y., Ma, M. J., Araki, M.,
Araki, K., Lee, S., Lee, I. S., Choi, E. Y.,
Interaction of CD99 with its paralog CD99L2 positively regulates
CD99L2 trafficking to cell surfaces.
J. Immunol., 191, 5730-5742 (2013).
(59) Semba, K., Araki, K., Matsymoto, K., Suda, H., Ando, T.,
Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M.,
Yamada, G., Nakagata, N., Iida, A., Ikegawa, S., Nakamura, Y.,
Araki, M., Abe, K., Yamamura, K.,
Ectopic Expression of Ptf1a Induces Spinal Defects, Urogenital Defects,
and Anorectal Malformations in Danforth’s Short Tail Mice.
PLoS Genetics, 9, e1003204 (2013).
(58) 武井直樹、荒木正健、渡邊貫之、熊谷周一朗、小西一之
自然哺乳子ウシから分離されたLactobacillus amylovorus Strain
Kumamoto (JCM14931)の整腸剤としての可能性
Animal Behaviour and Management, 48, 125-134 (2012).
(57) Park H. J., Byun D., Lee A. H., Kim J. H.,
Ban Y. L., Araki, M., Araki, K., Yamamura, K. I., Kiim I.,
Park S. H., Jung, K. C.,
CD99-Dependent Expansion of Myeloid-Derived Suppressor Cells and
Attenuation of Graft-Versus-Host Disease.
Molecules and Cells, 33, 259-267 (2012).
(56) Kim, H. R., Leon, B. H.,Im S. H., Araki, M., Araki, K.,
Yamamura, K. I., Choi S. C., Park D. S., Jun, C. D.,
IGSF4 is a novel TCR zeta-chain-interacting protein that enhances
TCR-mediated signaling.
J. Exp. Med., 208, 2545-2560 (2011).
(55) Kim, Y. D., Lee, J. Y., Oh, K. M., Araki, M., Araki, K.,
Yamamura, K. I., Jun, C. D.,
NSrp70 is a novel nuclear speckle-related protein that modulates
alternative pre-mRNA splicing in vivo.
Nucleic Acids Res., 39, 4300-4314 (2011).
(54) Suda, H., Lee, K. J., Semba, K., Kyushima, F., Ando, T., Araki, M.,
Araki, K., Inomata, Y., Yamamura, K.,
The Skt gene, required for anorectal development, is a candidate for
a molecular marker of the cloacal plate.
Pediatr. Surg. Int., 27, 269-273 (2010).
(53) Ando, T., Semba, K., Suda, H., Sei, A., Mizuta, H., Araki, M., Abe, K.,
Imai, K., Nakagata, N., Araki, K., Yamamura, K.,
The floor plate is sufficient for development of the sclerotome and spine
without the notochord.
Mech. Dev., 128, 129-140 (2010).
(52) Araki, K., Okada, Y., Araki, M., Yamamura, K.,
Comparative analysis of right-element mutant lox sites
on recombination efficiency in embryonic stem cells.
BMC Biotechnol., 10, 29 (2010).
(51) Vanhoutteghem, A., Maciejewski-Duval, A., Bouche, C.,
Delhomme, B., Herve, F., Daubigney, F., Soubigou, G.,
Araki, M., Araki, K., Yamamura, K. and Djian, P.,
Basonuclin 2 has a function in the multiplication of
embryonic craniofacial mesenchymal cells and is
orthologous to disco proteins.
Proc. Natl. Acad. Sci.,106, 14432-14437 (2009).
(50) 荒木正健
『LMO (Living Modified Organism)のABC：遺伝子組換え生物等規制法の再確認』
細胞工学別冊『バイオリソース＆データベース活用術：Webでキャッチ！！
実験材料・インフォマティクス』、276-286 (2009).
(49) 荒木正健、荒木喜美
『IGTC：ノックアウトマウスを作製する前にチェックすべき変異ESデータベース 』
細胞工学別冊『バイオリソース＆データベース活用術：Webでキャッチ！！
実験材料・インフォマティクス』、72-80 (2009).
(47) Toyota, N., Takano-Ohmuro, H., Yoshida, L. S., Araki, M.,
Yoshinobu, K., Suzuki-Toyota, F.,
Suppression of cardiac troponin T induces reduction
of contractility and structural disorganization in chicken
cardiomyocytes.
Cell Struct. Funct., 33, 193-201 (2008).
(46) Zhao, G., Li, Z., Araki, K., Haruna, K., Yamaguchi, K.,
Araki, M., Takeya, M., Ando, Y., Yamamura, K.,
Inconsistency between hepatic expression and
serum concentration of transthyretin in mice humanized
at the transthyretin locus.
Genes Cells, 13, 1257-1268 (2008).
(45) Chen, H., Li, Z., Haruna, K., Semba, K., Araki, M.,
Yamamura, K., Araki, K.,
Early pre-implantation lethality in mice carrying
truncated mutation in the RNA polymerase 1-2 gene.
Biochem. Biophys. Res. Commun., 365, 634-642 (2008) .
(44) Oishi, H., Mizuki, S., Terada, M., Kudo, M., Araki, K.,
Araki, M., Nose, M., Takahashi, S.,
Increased expression of soluble form of vascular
cell adhesion molecule-1 aggravates autoimmune
arthritis in MRL-Fas(lpr) mice.
Pathol. Int., 57, 734-740 (2007).
(43) Araki, K., Araki, M.,Yamamura, K.
Negative selection with the Diphtheria toxin A fragment
gene improves frequency of Cre-mediated cassette exchange
in ES cells.
J. Biochem., 140, 793-798 (2006).
(42) 荒木正健
『LMO (Living Modified Organism)のABC：遺伝子組換え生物等規制法の再確認』
細胞工学、25 (7), 792-798 (2006).
(41) 荒木正健、荒木喜美
使ってみよう！ バイオデータベース『IGTC』
細胞工学、25 (6), 664-671 (2006).
(40) Miura, K., Yoshinobu, K., Imaizumi, T., Haruna, K., Miyamoto, Y.,
Yoneda, Y., Nakagata, N., Araki, M., Miyakawa, T., Yamamura, K., Araki, K.
Impaired expression of importin/karyopherin beta1 leads to
post-implantation lethality.
Biochem. Biophys. Res. Commun., 341, 132-138 (2006).
(39) 荒木正健、山崎由紀子
新連載『使ってみよう！ バイオデータベース』連載を始めるにあたって
細胞工学、24 (11), 1206 (2005).
(38) Semba, K., Araki, K., Li, Z., Matsumoto, K. I., Suzuki, M.,
Nakagata, N., Takagi, K., Takeya, M., Yoshinobu, K., Araki, M., Imai, K.,
Abe, K., and Yamamura, K.
A novel murine gene, Sickle tail (Skt), linked to
the Danforth's short tail (Sd) locus, is required for normal
development of the intervertebral disc.
Genetics, 172, 445-456 (2006).
(37) Ohmuraya, M., Hirota, M., Araki, M., Mizushima, N., Matsui, M.,
Mizumoto, T., Haruna, K., Kume, S., Takeya, M., Ogawa, M., Araki, K.,
and Yamamura, K.
Autophagic cell death of pancreatic acinar cells in serine
protease inhibitor Kazal type 3-deficient mice.
Gastroenterology, 129, 696-705 (2005).
(36) Taniwaki, T., Haruna, K., Nakamura, H., Sekimoto, T., Oike, Y.,
Imaizumi, T., Saito, F., Muta, M., Soejima, Y., Utoh, A., Nakagata, N.,
Araki, M., Yamamura, K., and Araki, K.
Characterization of an exchangeable gene trap using pU-17
carrying a stop codon-beta geo cassette.
Dev. Growth Differ., 47, 163-172 (2005).
(35)Sakaguchi, N., Kimura, T., Matsushita, S., Fujimura, S., Shibata, J.,
Araki, M., Sakamoto, T., Minoda, C., and Kuwahara, K.,
Generation of High-Affinity Antibody against T Cell-Dependent
Antigen in Ganp Gene-Transgenic Mouse
J. Immunol., 174, 4485-4494 (2005).
(34)豊田直二、吉信公美子、荒木正健
RNA干渉は鶏心筋の一次培養細胞の筋蛋白質トロポニンＴの発現を抑制した
熊本学園大学論集『総合科学』第11巻第１号（通巻第21号）, 63-74 (2004).
(33)荒木正健
これを守らないと罰せられます 〜２月１９日施行！ 遺伝子組換え生物等規制法〜
細胞工学, 23 (4), 484-491 (2004).
(32)Hino, H., Araki, K., Uyama, E., Takeya, M., Araki, M., Yoshinobu, K., Miike, K.
Kawazoe, Y., Maeda, Y., Uchino, M., Yamamura, K.,
Myopathy phenotype in transgenic mice expressing mutated PABPN1
as a model of oculopharyngeal muscular dystrophy.
Hum. Mol. Genet., 13, 181-190 (2004).
(31)荒木正健、荒木喜美
大規模遺伝子トラップの現状 〜リソースとしての疾患モデルマウス〜
医学のあゆみ, 203 (3), 201-205 (2002).
(30)Noguchi, H., Kaname, T., Sekimoto, T., Senba, K., Nagata, Y., Araki, M.,
Abe, M., Nakagata, N., Ono, T., Yamamura, K., Araki, K.
Naso-maxillary deformity due to frontonasal expression of human
transthyretin gene in transgenic mice.
Genes to Cells, 7, 1087-1098 (2002).
(29)Araki, K., Araki, M., Yamamura, K.
Site-directed integration of the cre gene mediated by Cre recombinase
using a combination of mutant lox sites.
Nuc. Acids Res., 30 (19), e103 (2002).
(28)Takahashi, S., Araki, K., Araki, M., Ito, M., Nakatani, K., Fujii, H., Izui, S.,
Vassalli, P., and Nose, M.
Suppression of experimental lupus nephritis by aberrant expression
of the soluble E-selectin gene.
Pathology International, 52, 175-180 (2002).
(27)Kawazoe, Y., Sekimoto, T., Araki, M., Takagi, K., Araki, K., and Yamamura, K.
Region-specific gastrointestinal Hox code during murine embryonal
gut development.
Dev. Growth Differ., 44 (1), 77-84 (2002).
(26)Azuma, A., Takahashi, S., Nose, M., Araki, K., Araki, M., Takahashi, T.,
Hirose, M., Kawashima, H., Miyasaka, M., Kudoh, S.
Role of E-selectin in bleomycin induced lung fibrosis in mice.
THORAX, 55, 147-152 (2000).
(25)Imaizumi, T., Araki, K., M., Miura, K., Araki, M., Suzuki, M., Terasaki, H.,
Yamamura, K.
Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis:
Crk-II is not essential for embryonic development.
Biochem. Biophys. Res. Commun., 266, 569-574 (1999).
(24)Araki, K., Imaizumi, T., Sekimoto, T., Yoshinobu, K., Yoshimuta, J.,
Akizuki, M., Miura, K., Araki, M., Yamamura, K.
Exchangeable gene trap using the Cre/mutated lox system.
Cellular and Molecular Biology, 45, 737-750 (1999).
(23)Mizuki, S., Kamogawa, J., Terada, M., Takahashi, S., Araki, K., Araki, M.,
Vassalli, P., Okumura, H., Shibata, T., Nose, M.
Accelerative effects of soluble VCAM-1 on the development and
progression of arthritis in MRL-lpr/lpr mice.
Proceedings of the 10th International Congress of Immunology,
November 1-6, 1998, New Delhi, India
(22)Inoue, J., Iwaoka, T., Tokunaga, H., Takamune, K., Naomi, S., Araki, M.,
Takahama, K., Yamaguchi, K., Tomita, K.
A family with Liddle's syndrome caused by a new missense mutation
in the beta subunit of the epithelial sodium channel.
J. Clinical Endocrinology and Metabolism., 83, 2210-2213 (1998).
(21)Sekimoto, T., Yoshinobu, K., Yoshida, M., Kuratani, S.,
Fujimoto, S., Araki, M., Tajima, N., Araki, K. and Yamamura, K.,
Region- specific expression of murine Hox genes implies
the Hox code- mediated patterning of the digestive tract.
Genes to Cells, 3, 51- 64 (1998).
(20)Fujimoto, S., Araki, K., Chisaka, O., Araki, M., Takagi, K. and Yamamura, K.,
Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript
encodes a truncated protein lacking the homeodomain.
Gene, 209, 77-85 (1998).
(19)Araki, M., Araki, K., Biancone, L., Stamenkovic, I., Izui, S., Yamamura, K.
and Vassalli, P.,
The role of E-selectin for neutrophil activation and tumor metastasis
in vivo.
Leukemia, 11 (3), 209-212 (1997).
(18)Gotoh, T., Araki, M. and Mori, M.,
Chromosomal localizasion of the human arginase II gene and tissue
distribution of its mRNA.
Biochem. Biophys. Res. Commun., 233 (2), 487-491 (1997).
(17)Araki, K., Araki, M. and Yamamura, K.,
Targeted integration of DNA using mutant lox sites in embryonic stem cells.
Nuc. Acids Res., 25 (4), 868-872 (1997).
(16)Araki, M., Araki, K., Miyazaki, Y., Iwamoto, M., Izui S., Yamamura, K.
and Vassalli, P.
E-selectin binding promotes neutrophil activation in vivo:
A study of blood leukocytes in E-selectin transgenic mice.
Biochem. Biophys. Res. Commun., 224, 825- 830 (1996).
(15)Osanai, T., Feizi, T., Chai, W., Lawson, A. M., Gustavsson, M. L., Sudo, K.,
Araki, M., Araki, K. and Yuen, C.-T.
Two families of murine carbohydrate ligands for E-selectin.
Biochem. Biophys. Res. Commun., 218, 610-615 (1996).
(14)Biancone, L., Araki, M., Araki, K., Vassalli, P. and Stamenkovic, I.,
Redirection of tumor metastasis by expression of E-selectin in vivo.
J. Exp. Med., 183, 581-587 (1996).
(13)Garcia, I., Miyazaki, Y., Araki, K., Araki, M., Lucas, R., Grau, G. E., Milon, G.,
Belkaid, Y., Montixi, C., Lesslauer, W. and Vassalli, P.
Transgenic mice expressing high levels of soluble TNF-R1 fusion protein
are protected from lethal septic shock and cerebral malaria, and are highly
sensitive to Listeria monocytogenes and Leishmania major infections.
Eur. J. Immunology, 25, 2401-2407 (1995).
(12)Araki, K., Araki, M., Miyazaki, J., and Vassalli, P.,
Site-specific recombination of transgene in fertilized eggs by transiently
expressed Cre recombinase.
Proc. Natl. Acad. Sci., 92, 160-164 (1995).
(11)Araki, M., Araki, K., and Vassalli, P.,
Cloning and sequencing of mouse VCAM-1 cDNA.
Gene, 126, 261-264 (1993).
(10)Ichikawa, M., Araki, M., Rikihisa, T., Uchida, T., Shikata, T., and Mizuno, K.,
Cloning and expression of cDNAs from enterically-transmitted
Non-A, Non-B Hepatitis Virus.
Microbiol. Immunol., 35, 535-543 (1991).
(9)Araki, K., Shiosaki, K., Araki, M., Chisaka, O. and Matsubara, K.,
The essential region for assembly and particle formation in hepatitis B
virus surface antigen produced in yeast cells.
Gene, 89, 195-201 (1990).
(8)Yamaguchi, M., Hirano, T., Sugahara, K., Mizokami, H. Araki, M.
and Matsubara, K.,
Electron microscopy of Hepatitis B virus core antigen expressing yeast
cells by freeze-substitution fixation.
European J. Cell Biology, 47, 138-143 (1988).
(7)Matsubara, K., Ochiya, T., Hatada, I., Shiozawa, M., Fukushige, S.,
Araki, M., Fujiyama, A. and Tsurimoto, T.,
A Novel Oncogene from a Human Hepatocellular Carcinoma.
Oncogenes and Cancer, S. A. Aaronson et al (EDS.),
Japan Sci. Soc. Press, Tokyo/VNU Sci. Press,
UTRECHT, pp. 133-141, (1987).
(6)Imamura, T., Araki, M., Miyanohara, A., Nakao, J. Yonemura, H.,
Ohtomo, N. and Matsubara, K.,
Expression of Hepatitis B Virus Middle and Large Surface Antigen
Genes in Saccharomyces cerevisiae.
J. Virol., 61, 3543-3549 (1987).
(5)Matsubara, K., Tsurimoto, T., Ochiya, T., Shiozawa,M., Hatada, I. and Araki, M.,
Molecular Biological Studies on Hepatitis B Virus:
Replication and Tumor Production.
Proceedings of the 1st International Symposium
on Viral Hepatitis and Hepatocellular Carcinoma,
December 11-13, 1986, Taipei
(4)Miyanohara, A., Imamura,T., Araki,M., Sugawara,K., Ohtomo,N. and Matsubara,K.
Expression of Hepatitis B Virus Core Antigen Gene in Saccharomyces cerevisiae :
Synthesis of Two Polypeptides Translated from Different Initiation Codons.
J. Virol., 59, 176-180 (1986).
(3)Sanemasa, I., Arakawa, S., Araki, M. and Deguchi, T.,
The Effects of Salts on the Solubilities of Benzene, Toluene, Ethylbenzene,
and Propylbenzene in Water.
Bull. Chem. Soc. Jpn., 57, 1539-1544 (1984).
(2)Sanemasa, I., Araki, M., Deguchi, T. and Nagai, H.,
Solubility Measurements of Benzene and the Alkylbenzenes
in Water by Making Use of Solute Vapor.
Bull. Chem. Soc. Jpn., 55, 1054-1062 (1982).
(1)Sanemasa, I., Araki, M., Deguchi, T. and Nagai, H.
Solubilities of benzene and the alkylbenzenes in water.
--- Method for obtaining aqueous solutions saturated
with vapors in equilibrium with organic liquids ---
Chemistry Letters, 225-228 (1981).