熊本大学
生命資源研究・支援センター
遺伝子実験施設
熊本市本荘２－２－１
Tel : (096) 373-6501, FAX : (096)373-6502
２００３年 ７月 ７日 更新
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アクティブボード・２００３年６月研究発表を行った学会；第６１回日本癌学会総会２００２年１０月１日～４日（東京） タイトル；RAG1発現を指標とした初期リンパ前駆細胞の同定 発表者；五十嵐 英哉 氏 （熊本大学 熊本大学大学院医学薬学研究部 感染・免疫学講座 免疫分野） Abstract； Viable Lin- CD27+ c-kitHi Sca-1Hi GFP+ cells recovered from heterozygous RAG1/GFP knock-in mice progressed through previously defined stages of B, T and NK cell lineage differentiation. In contrast to the GFP- cohort, there was minimal myeloid or erythroid potential in cells with an active RAG1 locus. Overlap with TdT+ cells suggested that distinctive early lymphocyte characteristics are not synchronously acquired. Rearrangement of Ig genes initiates before typical lymphoid lineage patterns of gene expression are established, and activation of the RAG1 locus transiently occurs in a large fraction of cells destined to become NK cells. These early lymphocyte precursors (ELP) are distinct from stem cells, previously described pro-lymphocytes or progenitors corresponding to other blood cell lineages. |