研究発表を行った学会； Keystone symposia　-Chemokines and Chemokine Receptors-
　　　　２００６年　１月１５日〜２０日（ Utah, USA ）
タイトル； Selective expression and function of chemokine receptor CCR6 on effector memory human CD8+ T lymphocytes
発表者；近藤　孝昭　氏
　　　（熊本大学　エイズ学研究センター　ウイルス制御分野）
Abstract；
Human memory CD8+ T cells are composed of heterogeneous populations called central and effector memory T cells. A previous study showed that CCR6 is expressed on a part of CD8+ T cells although the populations expressing this receptor still remain uncharacterized. In this study, we investigated the expression and function of CCR6 on human CD8+ T cells.
Multi-color flowcytometric analysis revealed that the CCR6+ cells were predominantly found in CD27+CD28+CD45RA- subset and that most CCR6+ cells in this subset expressed CCR7-CCR5+ phenotype and a low level of perforin and gramzyme A. CCR6+ CD8+ T cell subsets produced significantly more IFN-�g�and TNF-�a� than the CCR6- subset, while the former subset produces less IL-2 than the latter. CD8+ T cell effectively migrated in response to CCL20 that is ligand for the CCR6. These findings indicate that CCR6 is expressed on the effector memory CD8+ T cells. In addition, the present study imply that CCR6+ memory CD8+ T cells migrate to inflammatory sites and the tissues such as colon.