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アクティブボード・２００１年１２月
研究発表を行った学会；14th International Congress of Developmental Biology
２００１年７月８日〜１２日（京都）
タイトル；Essential role of the QK1 RNA binding protein in embryonic blood vessel development.
発表者；李 正花
（発生医学研究センター 器官形成部門・臓器形成分野）
Abstract；
Quaking is an autosomal recessive mutation that exhibits pleiotropic phenotypes, tremor, male sterility and embryonic lethality. qkI, encoding a KH domain RNA binding protein, was isolated as a candidate gene for this mutation in 1996. Genetic and molecular biological studies using these mutant mice revealed that qkI is required for myelination in CNS as well as for developmental processes in some animals including a mouse.
Here, we studied the function of qkI in embryonic development using embryos homozygous for the targeted null allele of the qkI. Both in vivo and in vitro studies demonstrated that the embryonic lethality is primarily due to the defect in remodeling of the blood vessel structures caused by the deficiency of smooth muscle cells (SMC), and that QKI protein has a critical regulatory role in SMC development during embryonic blood vessel formation.
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